Whether it is bio-media, bio-data, synthetic biology, machine learning, or artificial life, these propositions explore not so much the biological imagination between technological hardware and software, but rather the ultimate limits of the relationships between humans, multiple organisms, and technological media. When life becomes a complex micro module, which can be transcoded and transposed across matter and media, and generates a vast network of emotional consciousness and perceptual memories, the form of life’s embodiment has shifted from “genetic messages” to “digital messages” in various combinations. Besides, it is deeply coded in the network of daily life for infinite replication, reproduction, and rematerialization that we are facing more than a complex and invisible life message system. As Roy Ascott, the pioneer of new media art in the UK, proposed, the “hypercortex” constructed in his “moist media” attempts to integrate the body, the cortex, and the massive messaging environment into an indivisible whole. Such “system” is the sum of “ubiquitous intelligence” and “technoetic arts,” meaning the extension of intelligence to every part of the environment, the combination of technology and intuition to produce new knowledge, the connections giving rise to new realities, and the new definitions toward life and human identity. Today, almost twenty years after the advent of “hypercortex” and ” moist media, ” art is still trying to find new languages, metaphors, and ways that go beyond realities and redefine itself in algorithms, technology cybernetics, and artificial intelligence. Consequently, through three dimensions of “Distributed Subjects – Machine Feeling”, “Wetware．Wet Data”, and “Alien Matter—Translational Matter,” the “HyperCortex – Post-Biocultural Forum” will examine the physical traces of the “hypercortex” in the post-biocultural environment.